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What is thiopental sodium

2025-10-04 20:25:44 healthy

What is thiopental sodium

Among the hot topics across the network in the past 10 days, a focus in the medical and health field is on the discussion of the anesthetic drug thiopental. This article will introduce in detail the definition, use, side effects and related hot data of sodium thiopental to help readers understand this drug comprehensively.

1. Definition and history of sodium thiopental

What is thiopental sodium

Thiopental Sodium is an ultra-short-acting barbiturate intravenous anesthetic, first discovered by American scientists in 1934 and applied to clinical practice. Because of its rapid onset and short-term effects, it is widely used in the induction of general anesthesia and short-term surgery.

propertydescribe
Chemical name5-ethyl-5-(1-methylbutyl)-2-thiobarbiturate sodium
Molecular formulaC11H17N2NaO2S
AppearanceWhite crystalline powder
SolubilityEasy to soluble in water, slightly soluble in ethanol

2. The main uses of sodium thiopental

The clinical application of thiopental sodium mainly includes the following aspects:

Use classificationSpecific application
Anesthesia inductionRapidly induce general anesthesia
Short-term surgeryFor short surgery within 15 minutes
Status of epilepsyControl refractory epilepsy seizures
Brain protectionReduce brain metabolic rate, used in brain surgery

3. Side effects and contraindications of sodium thiopental

Although thiopental sodium has significant anesthesia effects, its use also has certain risks and requires strict grasp of indications and contraindications.

Types of side effectsSpecific performance
Cardiovascular systemBlood pressure drops, heart rate slows down
Respiratory systemRespiratory depression, apnea
Allergic reactionsRash, bronchospasm
otherPain at the injection site, pharyitis

Contraindications of thiopental sodium include: porphyria, severe liver insufficiency, severe cardiovascular disease, hypovolemia shock, etc.

4. Recent hot discussions about sodium thiopental

According to the network data analysis in the past 10 days, the main discussions about sodium thiopental are focused on the following directions:

Discuss topicPopularity indexMain points
A shortage of anesthetic drugs85Tight supply of narcotics such as thiopental sodium is reported in many places around the world
Alternative drug research72Market share growth of new anesthetics such as propofol
Controversy about the use of drug for the death penalty68Some countries still use sodium thiopental as a death sentence injection
New discoveries on clinical applications55Research shows that sodium thiopental may have protective effects on certain brain damage

5. Comparison of sodium thiopental with other anesthetics

In clinical applications, sodium thiopental is often compared with other anesthetic drugs:

Comparison projectsSodium thiopentalPropofolMidazolam
Effective time30-45 seconds30-60 seconds2-5 minutes
Duration of action5-10 minutes4-8 minutes15-30 minutes
Cardiovascular effectsobviousmediumslight
Respiratory depressionpowerfulmediumweak

6. Precautions for using sodium thiopental

When using sodium thiopental, medical staff should pay attention to the following key points:

1) Must be used by an experienced anesthesiologist

2) Prepare tracheal intubation and respiratory support equipment before use

3) Closely monitor vital signs such as blood pressure, heart rate, and blood oxygen saturation

4) The elderly and frail patients need to use it less

5) Pay attention to drug interactions, especially with other central nervous system inhibitors

7. Market status of sodium thiopental

According to the latest market research data:

areamarket sharePrice TrendsMajor suppliers
North America35%StablizeHospira, Baxter
Europe28%A small increaseFresenius Kabi
Asia25%fluctuationHengrui Medicine, Renfu Medicine
Other regions12%Significant riseLocal suppliers

To sum up, thiopental sodium, as a classic intravenous anesthetic, still occupies an important position in the field of clinical anesthesia. With the development of medical technology and the emergence of new drugs, the scope and methods of use are also constantly being adjusted. Understanding the characteristics, indications and risks of this drug is of great significance to both medical practitioners and patients.

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